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Analysis and Detection of Quality Index of Virtual Welding Strength and Barrier Performance of Multi-chamber Infusion Soft Bag Products
Multi-chamber infusion soft bags are currently categorized into two main types in the large-scale infusion industry: liquid-liquid multi-chamber bags and powder-liquid multi-chamber bags. These products are designed to contain different infusion drugs within a single package, with each chamber separated by virtual welding. This design ensures that the components remain isolated during production, storage, and transportation. In clinical practice, the virtual weld is opened using external force, and after mixing, the contents are used immediately, as these multi-chamber soft bags are not suitable for long-term storage. Therefore, they are typically prepared on-site just before use.
This paper focuses on two critical quality factors: the performance of the virtual weld and the barrier properties of the multi-chamber infusion soft bags. The strength of the virtual weld is essential for ensuring both the safety of the product during storage and transportation and the ease of use in clinical settings. The weld must be strong enough to prevent accidental opening but not so strong that it becomes difficult to open. The heat sealing strength is determined by three key parameters: temperature, time, and pressure. To maintain this balance, manufacturers often rely on specialized equipment like Labthink’s HST-H3 heat seal tester and XLW (PC) intelligent electronic tensile tester to measure and control these parameters effectively.
In addition to weld strength, barrier performance plays a crucial role in maintaining the stability and integrity of the product. Both liquid-liquid and powder-liquid multi-chamber bags require an effective barrier to prevent the penetration of oxygen and moisture, which can degrade the drug quality. During the production process, nitrogen displacement packaging machines are used to replace the air inside the chambers, further enhancing the protective properties. Barrier tests typically include measuring oxygen permeability, nitrogen permeability, and water vapor transmission rate. Labthink’s VAC-V series of differential pressure gas permeameters are widely used for such assessments.
The application of multi-chamber infusion bags represents a significant advancement in the functionality of infusion soft bags. As part of strict pharmaceutical packaging requirements, these products must meet rigorous testing standards, including tensile strength, elongation, heat seal strength, film puncture resistance, rubber stopper puncture force, and overall sealing performance. Labthink has been a leading provider of testing instruments and services for the global pharmaceutical industry for many years. We are committed to delivering high-quality solutions to ensure product safety and compliance.
We look forward to expanding our collaboration with pharmaceutical companies and research institutions. For more information, please contact Guo Sijia at gz@labthink.com.