Pharmaceutical Raw Materials Clotrimazole 23593-75-1

Pharmaceutical Raw Materials Clotrimazole 23593-75-1

Model NO.: 23593-75-1
Einecs No.: 245-764-8
Mf: C22h17cln2
MW: 344.84
Product Categories: Pharmaceutical Intermediates
Transport Package: 25kg/Drum
Specification: bryan@pharm-china. com
Origin: Shanghai
HS Code: 3801100010
Model NO.: 23593-75-1
Einecs No.: 245-764-8
Mf: C22h17cln2
MW: 344.84
Product Categories: Pharmaceutical Intermediates
Transport Package: 25kg/Drum
Specification: bryan@pharm-china. com
Origin: Shanghai
HS Code: 3801100010

 
Product Description
 
Clotrimazole
Alias: Empecid
CAS: 23593-75-1 
EINECS No.: 245-764-8 
MF: C22H17ClN2 
MW: 344.84 
Purity: 99% 
Product Categories: Pharmaceutical Intermediates;Active Pharmaceutical Ingredients;Potassium channel;Aromatics;Heterocycles
Appearance: White powder 
Usage:Clotrimazole is an antifungal agent.
 

Our advantages:
1. High quality products with competitive prices
2. Professional service
3. Enough stock and Fast delivery
Terms of payment: T/T, Western Union, Money Gram
Way of shipping: EMS, DHL, FedEx, UPS
Delivery Time: Within 24 hours after payment
Packing: As required
We supply high quality products. Welcome for any inquiries



Usage for Clotrimazole: 
1. Clotrimazole is an Broad-spectrum antifungal medication, commonly used in the treatment of fungal infections of both humans(skin and deep fungal infection) and other animals such as vaginal yeast infections. Oral thrush, and ringworm. 
2. Clotrimazole is also used outside the local fungal infection to treat athlets's foot and jock itch. 
The main mechanism of action of clotrimazole highly selective fungal interfere with the activity of cytochrome P-450, thereby inhibiting the biosynthesis of ergosterol in the fungal cell membrane. 



COA:
 

Test Items		 Specification Test Results
Character A white or pale yellow crystalline powder Complies
Solubility Practically insoluble in water,soluble in alcohol and in methylene chloride , slight soluble in ether. Complies
Identification IR spectrum Similar to the standard. Complies

 		 Test TLC Principal spot of test solution is similar in position and size to the reference solution. Complies

 		 Color test In the test , an orange colour develops becoming orange-brown. Complies

 		 Melting point 141 to 145ºC 142.5 to 144ºC
Appearance of solution BY6 Solution is clear and not more instensely coloured than reference solution BY6 Complies
(2-Chlorophenyl)diphenylmethanol Not more than 0.2% Complies
Imidazole Not more than 0.2% Complies
Loss on drying Not more than 0.5% 0.11%
Sulphated ash Not more than 0.1% 0.05%
Content Not less than 98.5% and not more than 100.5% 99.3%
Conclusion UP to the BP2004 standard.
 

Indication:
It is commonly available as an over-the-counter substance in various dosage forms, such as a cream, vaginal tablet, or as a prescription troche or throat lozenge (prescription only). Topically, clotrimazole is used for vulvovaginal candidiasis (yeast infection) or yeast infections of the skin. For vulvovaginal candidiasis (yeast infection), clotrimazole tablets and creams are inserted into the vagina. Troche or throat lozenge preparations are used for oropharyngeal candidiasis (oral thrush) or prophylaxis against oral thrush in neutropenic patients.
Clotrimazole is usually used 5 times daily for 14 days for oral thrush, twice daily for 2 to 8 weeks for skin infections, and once daily for 3 or 7 days for vaginal infections.
Clotrimazole is also commonly used in conjunction with betamethasone as a topical cream for tinea corporis (ringworm), tinea cruris (jock itch), or tinea pedis (athlete's foot).
Topical and oral clotrimazole can be used in both adult and pediatric populations.
Additionally, clotrimazole may be used to treat the sickling of cells (related to sickle cell anemia).

Pregnancy:
Small amounts of clotrimazole may be absorbed systemically following topical and vaginal administration. However, this may still be used to treat yeast infections in pregnant women.

Side effects:
Side effects of the oral formulation include itching, nausea, and vomiting. >10% of patients using the oral formulation may have abnormal liver function tests. For this reason, liver function tests should be monitored periodically when taking the oral clotrimazole (troche). When used to treat vulvovaginal candidiasis (yeast infection), <10% of patient have vulvar or vaginal burning sensation. <1% of patients have the following side effects: Burning or itching of penis of sexual partner; polyuria; vulvar itching, soreness, edema, or discharge
Clotrimazole creams and suppositories contain oil which may weaken latex condoms and diaphragms.

Drug interactions:
There are no known significant drug interactions with topical clotrimazole. However, with oral (troche) clotrimazole, there are multiple interactions as the medication is a CYP450 enzyme inhibitor, primarily CYP3A4. Thus, any medication that is metabolized by the CYP3A4 enzyme will potentially have elevated levels when oral clotrimazole is used. The prescribing physician should be aware of any medication the patient is taking prior to starting oral clotrimazole. Certain medications should not be taken with oral clotrimazole. 
 
Product Description
 
Clotrimazole
Alias: Empecid
CAS: 23593-75-1 
EINECS No.: 245-764-8 
MF: C22H17ClN2 
MW: 344.84 
Purity: 99% 
Product Categories: Pharmaceutical Intermediates;Active Pharmaceutical Ingredients;Potassium channel;Aromatics;Heterocycles
Appearance: White powder 
Usage:Clotrimazole is an antifungal agent.
 

Our advantages:
1. High quality products with competitive prices
2. Professional service
3. Enough stock and Fast delivery
Terms of payment: T/T, Western Union, Money Gram
Way of shipping: EMS, DHL, FedEx, UPS
Delivery Time: Within 24 hours after payment
Packing: As required
We supply high quality products. Welcome for any inquiries



Usage for Clotrimazole: 
1. Clotrimazole is an Broad-spectrum antifungal medication, commonly used in the treatment of fungal infections of both humans(skin and deep fungal infection) and other animals such as vaginal yeast infections. Oral thrush, and ringworm. 
2. Clotrimazole is also used outside the local fungal infection to treat athlets's foot and jock itch. 
The main mechanism of action of clotrimazole highly selective fungal interfere with the activity of cytochrome P-450, thereby inhibiting the biosynthesis of ergosterol in the fungal cell membrane. 



COA:
 

Test Items		 Specification Test Results
Character A white or pale yellow crystalline powder Complies
Solubility Practically insoluble in water,soluble in alcohol and in methylene chloride , slight soluble in ether. Complies
Identification IR spectrum Similar to the standard. Complies

 		 Test TLC Principal spot of test solution is similar in position and size to the reference solution. Complies

 		 Color test In the test , an orange colour develops becoming orange-brown. Complies

 		 Melting point 141 to 145ºC 142.5 to 144ºC
Appearance of solution BY6 Solution is clear and not more instensely coloured than reference solution BY6 Complies
(2-Chlorophenyl)diphenylmethanol Not more than 0.2% Complies
Imidazole Not more than 0.2% Complies
Loss on drying Not more than 0.5% 0.11%
Sulphated ash Not more than 0.1% 0.05%
Content Not less than 98.5% and not more than 100.5% 99.3%
Conclusion UP to the BP2004 standard.
 

Indication:
It is commonly available as an over-the-counter substance in various dosage forms, such as a cream, vaginal tablet, or as a prescription troche or throat lozenge (prescription only). Topically, clotrimazole is used for vulvovaginal candidiasis (yeast infection) or yeast infections of the skin. For vulvovaginal candidiasis (yeast infection), clotrimazole tablets and creams are inserted into the vagina. Troche or throat lozenge preparations are used for oropharyngeal candidiasis (oral thrush) or prophylaxis against oral thrush in neutropenic patients.
Clotrimazole is usually used 5 times daily for 14 days for oral thrush, twice daily for 2 to 8 weeks for skin infections, and once daily for 3 or 7 days for vaginal infections.
Clotrimazole is also commonly used in conjunction with betamethasone as a topical cream for tinea corporis (ringworm), tinea cruris (jock itch), or tinea pedis (athlete's foot).
Topical and oral clotrimazole can be used in both adult and pediatric populations.
Additionally, clotrimazole may be used to treat the sickling of cells (related to sickle cell anemia).

Pregnancy:
Small amounts of clotrimazole may be absorbed systemically following topical and vaginal administration. However, this may still be used to treat yeast infections in pregnant women.

Side effects:
Side effects of the oral formulation include itching, nausea, and vomiting. >10% of patients using the oral formulation may have abnormal liver function tests. For this reason, liver function tests should be monitored periodically when taking the oral clotrimazole (troche). When used to treat vulvovaginal candidiasis (yeast infection), <10% of patient have vulvar or vaginal burning sensation. <1% of patients have the following side effects: Burning or itching of penis of sexual partner; polyuria; vulvar itching, soreness, edema, or discharge
Clotrimazole creams and suppositories contain oil which may weaken latex condoms and diaphragms.

Drug interactions:
There are no known significant drug interactions with topical clotrimazole. However, with oral (troche) clotrimazole, there are multiple interactions as the medication is a CYP450 enzyme inhibitor, primarily CYP3A4. Thus, any medication that is metabolized by the CYP3A4 enzyme will potentially have elevated levels when oral clotrimazole is used. The prescribing physician should be aware of any medication the patient is taking prior to starting oral clotrimazole. Certain medications should not be taken with oral clotrimazole. 

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