The United States invented new technology to induce cells to grow into artificial blood vessels

The United States invented new technology to induce cells to grow into artificial blood vessels

Release date: 2007-12-25

In a groundbreaking development, scientists from the Massachusetts Institute of Technology have introduced a novel technique that encourages cells to form parallel tube-like structures, potentially serving as artificial blood vessels in the future. The findings were published online in the journal Advanced Materials, marking a significant step forward in tissue engineering.

The research opens up new possibilities for creating nanosystems used in tissue regeneration. Focusing on vascular tissue—comprising capillaries and microvessels, which are crucial components of the circulatory system—the team developed a specialized surface that acts as a template for growing capillaries. Utilizing advanced micro-machines from the Draper Laboratory in Cambridge, they created nano-scale templates on silicone rubber substrates. These surfaces feature ridges and grooves that direct cell growth, enabling more precise control over the structure of the artificial vessels.

This technology could one day be used to implant artificial blood vessels into organs such as the kidneys, liver, or heart, where large amounts of vascular tissue are needed to transport nutrients, gases, and waste. Researchers believe this method is particularly effective with EPC (endothelial progenitor cells), which are more mature and capable of forming stable structures. Earlier attempts using other cell types failed to produce similar results. By culturing tissues on patterned surfaces, scientists can achieve greater consistency and control in their experiments.

In further tests, the team successfully transplanted lab-grown capillaries into living animals, aiming to integrate them with the host’s natural tissues. This progress brings us closer to the development of functional, bioengineered vascular systems that could revolutionize organ transplantation and regenerative medicine. — Shanghai Medical Device Industry Association

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