Disinfectants make bacteria resistant

An article in the October issue of Microbiology argues that chemicals used to kill bacteria in the environment will make bacteria stronger. The low concentrations of these chemicals, also known as antimicrobials, will allow Staphylococcus aureus to effectively remove these toxic chemicals from their bodies so that they may be resistant to some antibiotics.
Antimicrobial agents are used in disinfectants and preservatives to kill microorganisms. It is commonly used to clean the hospital and home environment, sterilize medical equipment, and pre-operative skin disinfection. Antimicrobial agents kill bacteria and other microorganisms at a certain intensity. However, if the amount used is not enough, the bacteria will continue to survive and develop resistance to the treatment.
"Staphylococcus aureus will make proteins that pump out a variety of toxic chemicals out of the bacteria and interfere with the therapeutic effects of antibiotics," said Glenn Carters of the U.S. Veterans Affairs Medical Center. "These protein pumps that can remove toxic chemicals can also remove antibiotics from bacteria, making them resistant to these drugs. We can also prevent bacteria from being killed by these protein pumps without killing them. Dead studied."
The researchers put Staphylococcus aureus extracted from the patient’s blood into several low-level antimicrobials and dyes that are routinely used in hospitals. They found that the mutation made these bacteria produce more protein pumps than normal.
"We found that exposure to various low concentrations of antimicrobial agents and dyes caused the emergence of bacterial tolerance variants," said Katz. “The number of protein pumps in bacteria has increased. Because these protein pumps can also remove antibiotics from bacteria, pathogenic bacteria with a large number of protein pumps pose a threat to patients because they are more tolerant to antibiotics.”
If bacteria are repeatedly exposed to antimicrobial agents, they will develop resistance to disinfectants and antibiotics. Most of these bacteria are bacteria that produce hospital-acquired infections.
"Scientists are trying to develop protein pump inhibitors. Effective inhibitors will reduce the possibility of bacteria tolerant." Katz said. "Unfortunately, some of the inhibitors that have been evaluated so far have no effect on various pathogens, so they are not ideal for preventing tolerance."
"The rational use of antibiotics and the use of antimicrobial agents that are not recognized by protein pumps will reduce the production of resistant strains," said Katz. "In other words, protein pump inhibitors combined with antibiotics or disinfectants will reduce the occurrence of these strains and their adverse clinical effects."

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