New vascular stent research is in full swing

Release date: 2010-06-24

Stent interventional therapy for cardiovascular disease is a revolution in clinical treatment technology. However, the clinical community has been controversial for problems such as in-stent restenosis and stent thrombosis, and related discussions and research reports have emerged one after another. In the recent academic activities held in the United States and Germany, scholars have reported on the latest research results of the stent, which is very worthy of attention.

Complete bioabsorbable drug stents performed well. The second phase of the ABSORB study, published at the 59th Annual Annual Meeting of the American College of Cardiology in Atlanta, USA, showed complete bioabsorbable drug elution for coronary artery disease. Coronary stent (BVS) had no thrombosis and no reoperation during cardiac intervention.
The clinical application of drug-eluting stents has solved the problem of restenosis after stent implantation in patients with coronary heart disease. However, individual studies have shown that drug-eluting stents may delay coronary endothelialization, cause allergic and inflammatory reactions, and increase late thrombotic events.
The ABSORB study was a prospective, non-randomized (open-blind) study in two phases. The study selected 131 patients from Australia, Belgium, Denmark, France, the Netherlands, New Zealand, Poland and Switzerland. The primary study endpoints included safety assessments and immediate surgical performance of fully biodegradable stents.
Professor Patrick W. Serruys, principal investigator of the Heart Center at Erasmus University Hospital in Rotterdam, Netherlands, said: "This good result has made me more convinced that one can be absorbed by the body after the blood vessels are restored to the bloodstream and eventually disappear completely. The device is the next reasonable attempt to treat coronary heart disease. The ABSORB study predicts that this technology is expected to revolutionize heart disease intervention."
Professor Ge Junbo, director of the Department of Cardiology, Shanghai Zhongshan Hospital, said: "These encouraging data show that BVS can restore blood flow without causing thrombosis or reoperation. This indicates that it has important clinical benefits for patients. If BVS can Continued to show good results in clinical studies, it has the potential to become a standard treatment for coronary heart disease."

New drug stents enable the smooth flow of superficial femoral artery in most patients with PAD. Dr. Dierk Scheinert of the Leipzig Park Hospital in Germany released a 787 patient with peripheral arterial disease (PAD) at the European Conference of Percutaneous Cardiovascular Interventions (EuroPCR). The study showed that 86.2% of patients with the new Zilver PTX drug-coated peripheral stent were able to maintain arterial vascular access within 12 months after surgery without additional interventional procedures.
Peripheral arterial disease (PAD) has become a common disease in the elderly population in China. In recent years, the incidence rate has increased significantly, but it has not received sufficient attention in clinical practice. PAD can lead to femoral artery stenosis and insufficient blood supply, while the effect of simple drug treatment is limited. Amputation and vascular bypass surgery are extremely traumatic to the body, and the bypass vascular occlusion rate is high. In recent years, interventional therapy has rapidly replaced surgery and has become the treatment of choice by virtue of minimally invasive, rapid improvement of patient symptoms and improvement of quality of life. However, because the primary disease of the patient cannot be completely eliminated, after the ordinary metal stent is implanted into the stenotic lesion, most of the stent will have in-stent restenosis, which requires re-intervention.
“I think this smooth data is very ideal. The rate of restenosis is more than 50%. It is very exciting and positive.” Dr. Scheinert said, “I am looking forward to seeing the final data after random research. Treatment of severe damage in the superficial femoral artery may be an important advance."
It is understood that the Zilver PTX stent is the first drug-coated stent for the treatment of superficial femoral artery disease. Zilver PTX has the advantage of achieving targeted delivery of paclitaxel compared to other drug-coated stents, rather than attaching the drug to the stent surface via a polymer. This eliminates the potential risks of polymer coatings, including clot formation and associated inflammation.

(Source: China Medical News)

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