LCZ696 (Valsartan/sacubitril) is a combination drug for use in heart failure developed by Novartis. It consists of the angiotensin receptor blocker valsartan and the neprilysin inhibitor sacubitril, in a 1:1 mixture by molecule count. It may be used instead of an ACE inhibitor or an angiotensin receptor blocker in people with heart failure with reduced ejection fraction. The combination is sometimes described as an "angiotensin receptor-neprilysin inhibitor" (ARNi).
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Lcz696 Intermediates,Cas 1426129-50-1,Cas 1012341-50-2,High Purity Lcz696 Intermediate Nanjing Sunshine Biotech Co., Ltd , http://www.sunshine-bio.com
Greenhouse vegetables have high yields, short cycle times, and can be picked a few vegetables a year, so they must have sufficient fertilizer supplements. The total input of compound fertilizers per hectare of greenhouse vegetables is as high as 1500-2250 kg. The original greenhouse vegetables are mostly applied to nitrogen fertilizer, and nitrogen fertilizers are mainly used ammonium sulfate, ammonium bicarbonate and urea are less used, because the latter two fertilizers in the greenhouse nitrogen concentration is high, prone to ammonia poisoning, resulting in many leafy vegetables The leaves are smaller and die, so the farmers are less likely to use them for safety reasons. The long-term application of ammonium sulfate in greenhouse vegetables will cause soil compaction, damage the soil structure and pollute the groundwater. In order to overcome the long-term application of ammonium sulfate hazards, farmers use ammonium bicarbonate and urea instead of ammonium sulfate, but a quarter of vegetables to be applied 5-6 times, using less frequent meals to overcome the volatilization of ammonia poisoning, but caused human and financial resources The waste. After the long-acting ammonium carbonate and long-acting urea were introduced, the use of greenhouse vegetables brought good news to farmers. The use of the above two nitrogen fertilizers to produce long-acting compound fertilizers is more ideal for vegetable production, and can provide significant production increase. According to the test results of vegetable bases in Dalian, when transplanting cucumbers and greenhouses in greenhouses, a one-time long-term compound fertilizer was applied at 1800-1950 kg/ha. During the entire growth and development of the crop and the fruit picking period, the former produced 9150 cucumbers per hectare. Kilograms, increase production of 11,250 kilograms of tomatoes, to obtain greater economic benefits.
It was approved under the FDA's priority review process on July 7, 2015. It is also approved in Europe.
We produce a series of complete intermediates for LCZ696, intermediate I (CAS No. 1426129-50-1) and intermediate II (CAS No. 1012341-50-2) etc.
Soil Fertigation Fertilizer Fertilizer
Water and fertilizer management of vegetables is the key to the high yield of vegetables. With the improvement of people's living standards and the development of the city, the variety, quantity, time-to-market, and regulation of off-season vegetables have become more and more important. The vegetable blue project has been raised to the important agenda of municipal construction. With the development of greenhouse vegetables, very seasonal vegetables have become a new independent planting system, which not only brings huge economic benefits to farmers, but also brings huge social benefits, and solves the difficulty of eating in winter in the north. South dish of the North. For example, the construction of the Shandong Shouguang Vegetable Base has greatly eased the vegetable supply market in Beijing and Tianjin. The development of greenhouse vegetables in Haicheng City of Liaoning Province has not only eased the vegetable market in major cities in Northeast China, but even exported to Russia. Due to the development of greenhouse vegetables, many townships and rural households have emerged from the poor and become rich.
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