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1 gas method
1.1 Fumigation and anti-mildew use chloropicrin (nitrochloroform), sulfur fumigation, etc. to play a role in anti-mildew. Due to their heavy pollution and heavy residue, the sulphur fumigation that has followed for centuries has basically stopped using. The chloropicrin is no longer used for curing Chinese herbal medicines and fumigation of aluminum phosphide. It is often used under plastic traps, low-dose synergies, or other methods.
1.2 Atmosphere storage The atmosphere storage is a new technology. Its principle is to adjust the gas conditions in the storage environment according to the will of the people. Since most molds and pests are living organisms, aerobic respiration is mostly performed. When the storage environment is filled with 98% oxygen or CO2 gas, the oxygen content drops to 5%-2%, and mold and pests will die due to lack of oxygen. Atmosphere storage is based on this principle to ensure that the storage is not mildew. Beijing Herbal Medicine Company uses CO2 filling method to reduce oxygen and kill insects. CO2 concentration is above 22% and oxygen is below 15%. After 5 months storage in summer, it shows good anti-mold effect. The determination of medicinal materials such as dried tangerine peel, Pueraria lobata, and licorice after CO2 enrichment showed that there were no significant differences in volatile oil, alkaloids, flavonoids, glycosides, etc., from the control group.
Lu Hongshan uses a barrel gas-dilution-enhancing 10 aq to observe the maintenance of animals that are susceptible to mildew, insects, and precious medicinal herbs. For 10 years, mildew, insects, oil, and discoloration have not appeared. This method is inexpensive and can be used. Convenience.
The advantages of modified atmosphere-enhancing Chinese medicine are light labor intensity, no pollution to the environment, and good preservation quality. Since 1978, it has been adopted in the medicinal materials sector and is currently a more advanced method of scientific expansion.
1.3 Ethylene Oxide Gas Sterilization Ethylene oxide gas has a strong diffusion force and penetrating power. There is a good killing effect on microorganisms. Some people have raw materials for the vitiligo pill, water pill, and honey pill. The ethylene oxide gas was introduced at 45° C. and 50% relative humidity for 4-8 hours. As a result, the total bacterial count decreased by more than 98.71%. The thin package spectrum and psoralen content showed significant changes. Ethylene oxide has some toxicity. Residues may remain in the drug and may also produce toxic substances such as 2-chloroethanol and ethylene glycol. Therefore, use caution.
2 Herbal volatile oil mildew
2.1 Clove oil, cinnamaldehyde Zhang Wenjuan found in the antifungal effect experiment, cinnamic aldehyde, clove oil MIF of 27 test molds were 62.5-100000μg/mL, 500-1250μg/mL, MFC were 125-5000μg /mL, 2500-5000μg/mL, cinnamic aldehyde can damage the fungal cell wall, so that the cytoplasm coagulation, organelles disappeared, resulting in the death of bacteria, used to simulate the anti-mildew test found that the simulation library within 3 months after the mold was not mildew, nor seen Insect mites were found to have mildew on the 55th day of dried Chinese herbal medicines, and insects were observed. After the simulation of the Chinese herbal medicine 1a, there was no mildew or gall of insecticide. The cinnamon aldehyde was used for the protection and re-use of Chinese herbal medicine. Low prices.
2.2 The lucid eggplant eggplant is a pepper plant, cubeplant, or wolfberry plant. The fruit contains about 5% volatile oil. Wu Shurong found in the anti-mildew of Chinese medicine powder, Chuanxiong, Codonopsis, Licorice each 1kg, with 2g cubeplant into the box containing the above-mentioned traditional Chinese medicine, observed at any time for 1 month, no mildew Trace phenomenon. The color and odor of the surface of the Chinese herbs after fumigation were unchanged. The fumigation of the volatile oil of cubea eggplant is used for the anti-mildew of Chinese medicinal materials, which has the advantages of low cost, good effect, simple method, and easy promotion.
3 Some traditional Chinese medicines such as kelp, kelp, and seaweed are used for anti-mildew Chen Cheng reports on Chinese herbal medicines. According to the 100:1 ratio of herbs, kelp is taken out and dried every 1 week. Then re-inserted into the stored medicine, so repeatedly used, the control found that after 7d of medicinal material into the kelp was significantly reduced the amount of bacteria, seaweed on the medicine itself without pollution, no odor.
4 Food Additives Used in Chinese Medicinal Materials Mildew dimethyl fumarate (DMF) is a new type of food additive researched abroad in the 1980s. Xu Yu et al. reported that DMF passes were used for the anti-mildew of Chinese herbal medicines. It was observed in DMF experiments on 13 kinds of Chinese herbal medicines to prevent molds and insects. If DMF is used properly, it may be effective to prevent mildew of Chinese medicinal materials, except DMF 100mg. In addition, there is a small amount of insects in the white stork phenomenon, the rest of the medicinal materials are not mildew mold, as a food additive DMF, for the protection of medicinal herbs every safe and reliable.
5 Conclusion Due to the use of Chinese herbal medicines for internal use, the anti-mold drugs used should be harmless to humans. In addition, there are many varieties of Chinese herbal medicines and their properties are different. It is also necessary to prove whether the anti-mold drugs have an influence on their composition. Therefore, the anti-mildew drugs are more complex, and the search for effective, safe, inexpensive and easy-to-use anti-mildew drugs has become an urgent research topic.
Anti-mildew method of Chinese medicinal materials
The phenomenon of mildew in Chinese medicine is very serious. According to the survey, the contamination rate of commercially available pieces of Chinese herbal medicine is 97.6%. The amount of pollution is between 510 and 3.55105, with an annual average of 3200/g. The average concentration of mold contaminated with traditional Chinese medicines is 3,657/g. The mildew of Chinese herbs not only causes tens of millions of yuan in economic losses each year. The changed active ingredients of traditional Chinese medicines change, affecting clinical efficacy, and some molds can produce toxins that are resistant to high temperatures, such as aflatoxins. The use of Chinese medicine contaminated by molds and their toxins causes mycotoxin disease, in addition to acute toxicity, It will also reduce cell division, inhibit protein synthesis, reduce immune function, and even cause mutations, abnormalities, and carcinogenesis. Therefore, the anti-mildew properties of Chinese herbal medicines are very important. The summary of the anti-mildew medicine in recent years is summarized.