British scientists invent new methods for organ transplantation using carbon monoxide

British scientists invent new methods for organ transplantation using carbon monoxide

Release date: 2007-10-29

British scientists invent new methods for organ transplantation using carbon monoxide According to a recent report by the BBC, researchers at the University of Sheffield in the United Kingdom have invented a method for the targeted release of small doses of carbon monoxide using carrier molecules. A carrier called "carbon monoxide releasing molecule" can be administered orally or by injection into a patient. This molecule is water-soluble and can quickly enter the bloodstream and is easily absorbed.
Carbon monoxide is a gas in the general sense, but micro-use is good for organ transplantation. British researchers have recently invented a new method that can effectively use carbon monoxide to help transplant organs survive while avoiding the risk of carbon monoxide poisoning.
Brian Mann, who led the study, said that the new method has two advantages. On one hand, it is convenient to control the dose of carbon monoxide in the patient, on the other hand, it is possible to determine the injection point or adjust the molecular design to point it to a specific site. No other parts of the body have an effect. Laboratory tests have shown good prospects for this approach, and researchers hope to begin human trials by 2010.
Inhalation of excessive carbon monoxide can cause human poisoning to die, but in organ transplant surgery, the trace amount of carbon monoxide helps to dilate blood vessels and reduce inflammation, thereby increasing the survival rate of transplanted organs. However, traditional carbon monoxide inhalation has the risk of causing patients and medical personnel to inadvertently inhale high doses of carbon monoxide. ——China Medicine 123 Network

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