Release date: 2017-08-10 Recently, a research team from the University of Utrecht in the Netherlands and the University of Belgian in Belgium conducted an experiment using a 3D printed vascular model to study the causes of arterial thrombosis. Arterial thrombosis can cause heart attacks and strokes, and can also be fatal. To this end, medical professionals want to better understand how blood clots are formed, and precise vascular models that mimic the interaction between blood vessel walls and blood flow can be of great help in this regard. The latest vascular model developed by Dutch and Belgian researchers replicated in most detail the 3D geometry of the artery and the pattern of blood flowing through the artery. The research team investigated the way blood clots are formed by narrowing blood vessels. They created a 3D model using CTA data from a real blood vessel, then printed it into a negative mold using stereolithography 3D printing, and then filled it with a mixture of polydimethylsiloxane (PDMS) and a crosslinker mixture. Mold. After curing, a microfluidic tube that mimics the vascular access is made. The wall of the microfluidic tube is coated with human umbilical vein endothelial cells (HUVEC). Subsequently, whole blood of humans with fluorescently labeled platelets is perfused at a physiologically relevant shear rate. The researchers successfully formed platelet aggregation leading to clot formation and observed an increase in reflux downstream of the narrowed blood vessels. The success of this innovative approach has made many other applications possible, such as the development of customized blood vessel models. This way of making blood vessels using 3D printing technology, in particular, it provides informative detail, high resolution and flow control, meaning that similar methods can be used in other vascular disease research, such as vascular dementia. Source: Tiangongshe Fufeng Sinuote Biotechnology Co.,Ltd. , https://www.sntbiology.com
Researcher 3D prints a microfluidic vascular model to study the causes of arterial thrombosis
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