Top Quality Axitinib CAS 319460-85-0 AG013736 for Advanced Kidney Cancer
1. Quick Details:
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Product name:
Axitinib;AG013736
Synonyms:
AXITINIB;Benzamide, N-methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]-;N-M
ETHYL-2-{[3-((E)-2-PYRIDIN-2-YLVINYL)-1H-INDAZOL-6-YL]SULFANYL}BENZAMIDE;N
Methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide;AVERMECTINB;Axitinib for research;AG 013736;N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]benzamide
CAS:
319460-85-0
MF:
C22H18N4OS
MW:
386.47
Density:Â
1.35g/cm3
Grade:
Pharmaceutical Grade
Character:
Off-White Solid
MOQ:
5 grams
Deliver time:
About 5 days
Shipping:
EMS, DHL, TNT, FedEx, UPS,ect(door to door)
2. What is Axitinib:
Axitinib (AG013736; trade name Inlyta) is a small molecule tyrosine kinase inhibitor developed byPfizer. It has been shown to significantly inhibit growth of breast cancer in animal (xenograft) models and has shown partial responses in clinical trials with renal cell carcinoma (RCC)and several other tumour types.
Axitinib is a cancer medication that interferes with the growth and spread of cancer cells in the body.Axitinib is used to treat cancer of the kidney.Axitinib is usually given after other cancer medication has been tried without successful treatment.Axitinib may also be used for purposes not listed in this medication guide.
3. Uses and fuction of Axitinib:
Axitinib is also called by its brand name Inlyta. It is a type of drug called a tyrosine kinase inhibitor, which is a cancer growth blocker. It blocks certain proteins called tyrosine kinases from acting on cells. Tyrosine kinases signal to cancer cells to grow.
Axitinib blocks different types of tyrosine kinase and is called a multi kinase inhibitor. It stops cancer cells forming blood vessels, which the cancer needs in order to grow. This is called anti angiogenesis treatment.
Axitinib is a treatment for advanced kidney cancer. You may also have it as part of a clinical trial for other cancers including soft tissue sarcoma and thyroid cancer.
Treatment of advanced renal cell carcinoma after the failure of one prior systemic therapy.
4. Echanism of action:
Its primary mechanism of action is thought to be Vascular endothelial growth factor receptor 1-3, c-KIT and PDGFR inhibition, this, in turn, enables it to inhibit angiogenesis (the formation of new blood vessels by tumours).
It was also proposed that it might act by inducing autophagy, as some other tyrosine kinase inhibitors, like sorafenib.
It has also been shown to bind (in a different conformation from the VEGF binding) to the BCR-ABL fusion protein, specifically inhibiting the drug-resistant T315I mutant isoform.
5. Storage:
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
6. Our  Adwantage:Â
  High quality with competitive price:Â
  1) Standard: Enterprise Standard
  2) All Purity:>=99%
  3) We are manufacturer and can provide high quality products with factory price.Â
  Fast and safe delivery:
  1) Parcel can be sent out in 24 hours after payment. Tracking number available
  2) Secure and discreet shipment. Various transportation methods for your choice.Â
  3) Customs pass rate: >=99%
  4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.Â
  We have clients throughout the world:
  1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.Â
  2) Market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility.Â
  3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.
  Everybody is talking the similar words, what I want to say is: Just give me a chance, Just have a try on me, maybe you will get a surprise from me! Â
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Top Quality Axitinib CAS 319460-85-0 AG013736 for Advanced Kidney Cancer
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