Study found that clinical drugs for Alzheimer's disease can repair tooth decay

Study found that clinical drugs for Alzheimer's disease can repair tooth decay

October 17, 2017 Source: Pharmaceutical Network

The study found that Aldegheimer's disease drug Tideglusib can promote stem cell regeneration in the pulp and repair dental caries. Dr. Nigel Carter, CEO of the Oral Health Foundation, said: "This is a very interesting and novel approach, it shows great promise, we will expect it to be converted into clinical applications, which is undoubtedly a treatment for dental disease. Great progress."

 
A study published in the Journal of Scientific Reports by King's College London found that this clinical drug for Alzheimer's disease, Tideglusib, promotes stem cell regeneration in the pulp and repairs cavities.

 
Generally speaking, if the pulp in the tooth is exposed to trauma or infection, the tooth will have the ability to regenerate dentin, but this can only produce a very thin layer, which is not enough to fill a large cavity. However, the researchers found that Tideglusib stimulates stem cells in the pulp to produce new dentin. This is because it shuts down an enzyme called gsk-3, which ultimately enhances the self-healing ability of the teeth.

By soaking a degradable small sponge with the drug and inserting it into the molar cavity, dentin growth can be triggered and the damage repaired within six weeks. These tiny sponges are made of collagen, so they fuse over time, leaving only the repaired teeth.

 
Professor Paul Sharpe from the Institute of Dental Research at King's College London said: "This simple method of treating large cavities by providing endodontic protection and repairing dentins makes it an ideal clinical dental product. Using a drug that has been tested in clinical trials of Alzheimer's disease allows this dental treatment to quickly enter the clinic."

Currently, dentists use artificial fillers such as calcium and silicon-based products to repair larger cavities. But these fillers are still on the teeth and cannot be broken down, which means that the normal mineral levels of the teeth are not fully recovered.

 
Dr. Nigel Carter, CEO of the Oral Health Foundation, said: "This is a very interesting and novel approach, it shows great promise, we will expect it to be converted into clinical applications, which is undoubtedly a treatment for dental disease. Great progress."

 
“Creating a more natural way to repair your teeth not only eliminates these problems, but it also has less trauma to the patient. In a situation where dental phobia is still common, a natural way to stimulate dentin renewal is used. It is a particularly gratifying proposal for these groups, because receiving treatment often causes great anxiety."

 
To date, this treatment has only been used on the teeth of mice, but it has been shown to "fill the entire lesion."
 

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